Digitek Pharmacology- (866)335-8999

Digitek (Digoxin) inhibits sodium-potassium ATPase, an enzyme that regulates the quantity of sodium and potassium inside cells. Inhibition of the enzyme leads to an increase in the intracellular concentration of sodium and thus (by stimulation of sodium-calcium exchange) an increase in the intracellular concentration of calcium.

The beneficial effects of Digitek (digoxin) result from direct actions on cardiac muscle, as well as indirect actions on the cardiovascular system mediated by effects on the autonomic nervous system. The autonomic effects include: (1) a vagomimetic action, which is responsible for the effects of Digitek (digoxin) on the sinoatrial and atrioventricular (AV) nodes; and (2) baroreceptor sensitization, which results in increased afferent inhibitory activity and reduced activity of the sympathetic nervous system and renin-angiotensin system for any given increment in mean ar terial pressure.

The pharmacologic consequences of these direct and indirect effects are: (1) an increase in the force and velocity of myocardial systolic contraction (positive inotropic action); (2) a decrease in the degree of activation of the sympathetic nervous system and renin-angiotensin system (neurohormonal deactivating effect); and (3) slowing of the heart rate and decreased conduction velocity through the AV node (vagomimetic effect).

The effects of Digitek (digoxin) in heart failure are mediated by its positive inotropic and neurohormonal deactivating effects, whereas the effects of the drug in atrial arrhythmias are related to its vagomimetic actions. In high doses, Digitek (digoxin)  increases sympathetic outflow from the central nervous system (CNS). This increase in sympathetic activity may be an important factor in Digitek(digitalis) toxicity.

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*Have you or someone you know taken any of the following medicines?
Digitek Bertek UDL Digoxin Lanoxin Lanoxicaps Other
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Digitalis Toxicity	Yes     No
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